التفاصيل البيبلوغرافية
| العنوان: |
Chimeric biomolecules: Biomolecular recognition-based self-organization at the bio-material interfaces |
| المؤلفون: |
Yuca, E., Utku, F.S., Spencer, P., Tamerler, C. |
| المساهمون: |
Yuca, E., Utku, F.S., Spencer, P., Tamerler, C., Yeditepe Üniversitesi |
| بيانات النشر: |
Elsevier Inc., 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Bio-material interface, Restorative materials, Bioenabled mineralization, Peptide engineering |
| الوصف: |
Biological structures have been a constant source of inspiration for the design of practical materials and systems. With a growing understanding of the processes involved, biological principles are now revisited as novel routes in materials assembly and fabrication for various technological applications. In Nature, molecular recognition is the means to guide the organization of hierarchical structures through self-assembly; self-assembly is achieved through the precise interactions of components with the surrounding molecules. The development of robust molecular tool kits for designing, engineering, and controlling the orientation, and the confinement of the biomolecules on the desired material surfaces can be a game changer in the next generation of biomaterials. Inspired by nature's elegant hierarchical organization, we mimic the molecular-scale interactions that are built upon molecular recognition and self-assembly at surfaces and interfaces. Our approach incorporates solid material-binding peptides that are engineered to have affinity and specificity to target inorganic surfaces. Using engineered peptides, we create self-organized surfaces and interfaces starting at the molecular scale. In this chapter, we summarize solid-binding peptide-based approaches specifically for restorative biomaterials. Starting from their design, we provide various examples of the application of these approaches. We also discuss the use of engineered peptides as chimeric molecules that link solid recognition ability to the existing repertoire of bioactive peptides, integrin-binding domains, as well as proteins, eg, green fluorescence, protein to monitor mineralization. The chapter ends with a future perspective on the utilization of peptide engineering approaches to design smart biomaterials-biomaterials that restore dental tissues by providing self-healing at the interface. © 2017 Elsevier Ltd. All rights reserved. |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od_____10007::8430dc4082c5382897d38a3628950b3e
https://hdl.handle.net/20.500.11831/7094 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.od.....10007..8430dc4082c5382897d38a3628950b3e |
| قاعدة البيانات: |
OpenAIRE |
