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PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[

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العنوان: PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[
المؤلفون: Alyssa C, Pollard, Vincenzo, Paolillo, Bhasker, Radaram, Sarah, Qureshy, Li, Li, Tapati, Maity, Lei, Wang, Md Nasir, Uddin, Christopher G, Wood, Jose A, Karam, Mark D, Pagel, David, Piwnica-Worms, Steven W, Millward, Natalie Wall, Fowlkes, William, Norton, Brian J, Engel, Federica, Pisaneschi, Niki M, Zacharias
المصدر: Molecular imaging and biology. 24(6)
سنة النشر: 2021
مصطلحات موضوعية: Mice, HEK293 Cells, Lung Neoplasms, Glutamine, Positron-Emission Tomography, Animals, Humans, RNA, Small Interfering, Carcinoma, Renal Cell, Magnetic Resonance Imaging, Kidney Neoplasms
الوصف: Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission tomography (PET) reporters are not used clinically to visualize altered glutamine metabolism in ccRCC, which greatly hinders detection, staging, and real-time therapeutic assessment. We sought to determine if (2S,4R)-4-[We generated a novel ccRCC lung lesion model using the ccRCC cell line UMRC3 stably transfected with GFP and luciferase constructs. This cell line was used for characterization of [In UMRC3 cells, [We report one of the first direct orthotopic mouse models of ccRCC lung lesions. Using PET/MR imaging, lung tumors were easily discerned from normal tissue. Higher uptake of [
تدمد: 1860-2002
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1c0211e7959ee3949c5fb1eae70d8d7e
https://pubmed.ncbi.nlm.nih.gov/35732988
رقم الأكسشن: edsair.pmid..........1c0211e7959ee3949c5fb1eae70d8d7e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18602002