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Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

التفاصيل البيبلوغرافية
العنوان: Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)
المؤلفون: Ivan O, Maslov, Tatiana V, Zinevich, Olga G, Kirichenko, Mikhail V, Trukhan, Sergey V, Shorshnev, Natalya O, Tuaeva, Maxim A, Gureev, Amelia D, Dahlén, Yuri B, Porozov, Helgi B, Schiöth, Vladimir M, Trukhan
المصدر: Pharmaceuticals (Basel, Switzerland). 15(3)
سنة النشر: 2021
الوصف: Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl peptidase-4) inhibitors. Compound
تدمد: 1424-8247
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::215fc0965c6480cc169177fda35b4fe0
https://pubmed.ncbi.nlm.nih.gov/35337071
حقوق: OPEN
رقم الأكسشن: edsair.pmid..........215fc0965c6480cc169177fda35b4fe0
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14248247