It has been proven that video assited thoracoscopic surgery (VATS) achieved the same survival rates compared with traditional open chest operation in the treatment of early stage of lung cancer. but it is unclear if there is any difference of body inflammatory reaction between the two operation. The aim of this study is to investigate the changes of inflammatory state of thoracoscopic radical lobectomy in early peripheral lung cancer patients.Senventy-one early peripheral lung cancer patients who have underwent radical lobectomy were divided into two groups based on the different operation method. The VATS group was treated by thoracoscopic lobectomy. The thoracotomy group was treated by traditional thoracotomy. Then the level of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-10 at 1-day before operation and 3-day, 7-day postoperation were measured and compared between the two groups.No significant difference was found in the level of serum CRP, TNF-α, IL-6 and IL-10 before operation. Compared to the thoracotomy group, the level of serum CRP, TNF-α, IL-6 and IL-10 in the VATS group were significantly lower after operation.Compared with thoracotomy lobectomy, thoracoscopic lobectomy for early peripheral lung cancer patients is associated with lower inflammatory responses .背景与目的 胸腔镜治疗早期肺癌在预后方面取得与传统开胸手术方式相同的效果，患者在这两种术式术后恢复方面是否存在差别是最近研究的热点。本研究旨在探讨胸腔镜治疗早期周围型肺癌根治术患者机体术后炎性状态变化。方法 选取71例于天津医科大学总医院行早期周围型肺癌根治术的患者为研究对象，根据手术方式不同分为胸腔镜组35例和开胸手术组36例，比较两组患者手术时间、出血量、淋巴结清扫个数、术后胸管留置时间、胸引量及术前1 d，术后3 d和术后7 d的C-反应蛋白（C-reactive protein, CRP）、α-肿瘤坏死因子（tumor necrosis factor-α, TNF-α）、白介素-6（interleukin-6, IL-6）、IL-10的水平。结果 两组患者手术时间、出血量、淋巴结清扫个数、术后胸管留置时间、胸引量无明显差异，术后CRP、TNF-α、IL-6和IL-10的水平均较术前升高，胸腔镜组患者的升高幅度小于开胸手术组。结论 胸腔镜行早期周围型肺癌根治术对患者机体术后炎性反应状态影响更小。
