Self-Organized Attractor Dynamics in the Developing Head Direction Circuit
| العنوان: | Self-Organized Attractor Dynamics in the Developing Head Direction Circuit |
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| المؤلفون: | Joshua P, Bassett, Thomas J, Wills, Francesca, Cacucci |
| المصدر: | Current Biology |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Bayes Theorem, anterodorsal thalamic nucleus, Article, Rats, attractor network, Anterior Thalamic Nuclei, Head Movements, Animals, Cues, Head, head direction cells, development, Orientation, Spatial |
| الوصف: | Summary Head direction (HD) cells are neurons found in an extended cortical and subcortical network that signal the orientation of an animal’s head relative to its environment [1, 2, 3]. They are a fundamental component of the wider circuit of spatially responsive hippocampal formation neurons that make up the neural cognitive map of space [4]. During post-natal development, HD cells are the first among spatially modulated neurons in the hippocampal circuit to exhibit mature firing properties [5, 6], but before eye opening, HD cell responses in rat pups have low directional information and are directionally unstable [7, 8]. Using Bayesian decoding of HD cell ensemble activity recorded in the anterodorsal thalamic nucleus (ADN), we characterize this instability and identify its source: under-signaling of angular head velocity, which incompletely shifts the directional signal in proportion to head turns. We find evidence that geometric cues (the corners of a square environment) can be used to mitigate this under-signaling and, thereby, stabilize the directional signal even before eye opening. Crucially, even when directional firing cannot be stabilized, ensembles of unstable HD cells show short-timescale (1–10 s) temporal and spatial couplings consistent with an adult-like HD network. The HD network is widely modeled as a continuous attractor whose output is one coherent activity peak, updated during movement by angular head velocity signals and anchored by landmark cues [9, 10, 11]. Our findings present strong evidence for this model, and they demonstrate that the required network circuitry is in place and functional early during development, independent of reference to landmark information. Highlights • Non-visual cues can anchor head direction (HD) cells in pre-eye-opening rat pups • Internal network dynamics are preserved even when the HD representation is unstable • Angular velocity under-signaling drives instability, which is mitigated by corners • Circuit architecture develops even before any landmarks can stabilize HD responses Bassett et al. show that the attractor architecture of the head direction (HD) circuit develops without reference to landmarks. Non-visual cues can stabilize HD responses in rat pups aged 13 days or older. Instability in pre-visual HD cells is caused by angular velocity under-signaling, mitigated by proximity to corners in square enclosures. |
| تدمد: | 1879-0445 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::4661cb8140e85ee81bb8e4cc57cb8047 https://pubmed.ncbi.nlm.nih.gov/29398220 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........4661cb8140e85ee81bb8e4cc57cb8047 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790445 |
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