أعرض في EDS

Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation

التفاصيل البيبلوغرافية
العنوان: Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation
المؤلفون: Hua-Rong, Zhou, Jian-Zhen, Shen, Hai-Ying, Fu, Feng, Zhang
المصدر: Current medical science. 41(5)
سنة النشر: 2021
مصطلحات موضوعية: Cell Survival, Sequence Analysis, DNA, Genistein, Methylation, Up-Regulation, DNA Demethylation, Gene Expression Regulation, Neoplastic, Histones, Leukemia, Myeloid, Acute, Cell Line, Tumor, Anticarcinogenic Agents, Humans, Phosphorylation, Wnt Signaling Pathway, Cell Proliferation
الوصف: To investigate the effects and mechanisms of genistein on the gene expression in the Wnt pathway in acute leukemia (AL) cells.The expression of Wnt pathway genes and cell cycle-related genes were analyzed in two AL cell lines. Pyrophosphate sequencing was performed to determine the methylation degree. Then, the enrichment of H4K20me1 and H3K9ac was determined using ChIP-qPCR. Flow cytometry was used to analyze the cell cycle.The ICGenistein inhibits the activation of the Wnt pathway by promoting the expression of
تدمد: 2523-899X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5cd7c7ada814f3e154d0e6997c92d01a
https://pubmed.ncbi.nlm.nih.gov/35435596
رقم الأكسشن: edsair.pmid..........5cd7c7ada814f3e154d0e6997c92d01a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:2523899X