[Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia]

التفاصيل البيبلوغرافية
العنوان: [Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia]
المؤلفون: Ri-Na, Su, Rong-Rui, Wei, Wei-Zao, Luo, Ji-Xiao, Zhu, Lu, Wang, Guo-Yue, Zhong
المصدر: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 44(9)
سنة النشر: 2019
مصطلحات موضوعية: Male, Mice, Epidermal Growth Factor, Proto-Oncogene Proteins c-bcl-2, Plant Extracts, Prostatic Hyperplasia, Animals, Medicine, Tibetan Traditional, Dihydrotestosterone, Urticaceae, Testosterone Propionate
الوصف: In this study,mouse models of benign prostatic hyperplasia induced by subcutaneous injection of testosterone propionate was used to investigate the therapeutic effect and mechanism of Urtica hyperborean( UW) extracts on prostate hyperplasia in mice. The effects of UW extracts on prostate index,serum epidermal growth factor( EGF) and dihydrotestosterone( DHT) in model mice were observed,and the EGF and anti-apoptotic factor( Bcl-2) mRNA expression levels were detected as well as pathological changes in prostate tissue. The results showed that the ethyl acetate extraction and alcohol soluble fraction of the UW could significantly reduce the prostate index,reduce the serum DHT and EGF levels( P0. 01),and significantly decrease the EGF and Bcl-2 mRNA expression( P0. 01),significantly improved the morphological structure of prostate tissue. The above results confirmed that ethyl acetate extract and alcohol-soluble parts of UW have a good preventive effect on mice prostatic hyperplasia model,and its mechanism may be to reduce androgen levels by regulating polypeptide growth factors and/or inhibiting cell hyperproliferation and promoting apoptosis. This study laid the foundation for the further research on UW.
تدمد: 1001-5302
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::83a30683de77f625ac3e7b26f44be01c
https://pubmed.ncbi.nlm.nih.gov/31342726
رقم الأكسشن: edsair.pmid..........83a30683de77f625ac3e7b26f44be01c
قاعدة البيانات: OpenAIRE