Effects of total iridoid glycosides of

التفاصيل البيبلوغرافية
العنوان: Effects of total iridoid glycosides of
المؤلفون: Xu, Xu, Wei-Ting, Wang, Zhuan-You, Zhao, Wen-Gong, Xi, Bing, Yu, Chun-Hua, Hao, Xin, Li, Wen-Bin, Hou, Li-da, Tang
المصدر: Chinese herbal medicines. 12(1)
سنة النشر: 2019
الوصف: To investigate the therapeutic effect of total iridoid glycosides ofSD rats were fed with high-fat and high-sugar diet for 8 weeks to establish NASH. TIGP were given orally at doses of 20, 40 and 80 mg/kg/d for 4 weeks. Triglycerides assay (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose (FPG), fasting insulin (FINS), tumor necrosis factor-α (TNF-The results showed that TIGP significantly decreased TC, TG and FFA in liver tissue, increased SOD activity, decreased MDA content, decreased serum levels of TG, TC, HDL-C/LDL-C, ALT, AST, GLU, HOMA-IR, TNF-TIGP had anti-fatty liver effect against NASH rats induced by high-fat and high-sugar diet. Its mechanism was related to the regulation of lipid metabolism and reduction of insulin resistance, through inhibition of oxidative stress and inflammation.
تدمد: 2589-3610
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::91d36e54c6184b16a25d1a0dae78961d
https://pubmed.ncbi.nlm.nih.gov/36121397
حقوق: OPEN
رقم الأكسشن: edsair.pmid..........91d36e54c6184b16a25d1a0dae78961d
قاعدة البيانات: OpenAIRE