Letter to the Editor response: Nygaard et al
| العنوان: | Letter to the Editor response: Nygaard et al |
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| المؤلفون: | Towfic, F., Kusko, R., Zeskind, B. |
| المصدر: | Biostatistics (Oxford, England) |
| بيانات النشر: | Oxford University Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Letter to the Editor |
| الوصف: | The article by Nygaard and others (2016) proposes that applying batch correction approaches to microarray data from studies with unbalanced designs may inadvertently exaggerate the differences observed. In seeking to illustrate their point, Nygaard and others (2016) utilized a dataset (GSE61901) from a study we published (Towfic and others, 2014) and showed that one analysis pipeline utilizing the traditional approach to batch correction (ComBat) yielded over 1000 differentially expressed probesets, while an alternative approach proposed by Nygaard and others (2016). (utilizing batch as a fixed effect and averaging technical replicates) recovered 11 differentially expressed probesets. |
| اللغة: | English |
| تدمد: | 1468-4357 1465-4644 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::9433c680c51afd87614ad5463b7ec56f http://europepmc.org/articles/PMC5379915 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........9433c680c51afd87614ad5463b7ec56f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14684357 14654644 |
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