CHILDHOOD MALTREATMENT PREDICTS REDUCED INHIBITION-RELATED ACTIVITY IN THE ROSTRAL ANTERIOR CINGULATE IN PTSD, BUT NOT TRAUMA-EXPOSED CONTROLS

التفاصيل البيبلوغرافية
العنوان: CHILDHOOD MALTREATMENT PREDICTS REDUCED INHIBITION-RELATED ACTIVITY IN THE ROSTRAL ANTERIOR CINGULATE IN PTSD, BUT NOT TRAUMA-EXPOSED CONTROLS
المؤلفون: Jennifer S, Stevens, Timothy D, Ely, Takehito, Sawamura, Dora, Guzman, Bekh, Bradley, Kerry J, Ressler, Tanja, Jovanovic
المصدر: Depression and anxiety. 33(7)
سنة النشر: 2016
مصطلحات موضوعية: Adult, Georgia, Adolescent, Urban Population, Middle Aged, Gyrus Cinguli, Magnetic Resonance Imaging, Severity of Illness Index, Article, Black or African American, Stress Disorders, Post-Traumatic, Inhibition, Psychological, Young Adult, Humans, Female, Child Abuse, Child, Stress, Psychological
الوصف: A deficit in the ability to inhibit fear has been proposed as a biomarker of posttraumatic stress disorder (PTSD). Previous research indicates that individuals with PTSD show reduced inhibition-related activation in rostral anterior cingulate cortex (rACC). The goal of the current study was to investigate differential influences of an early environmental risk factor for PTSD-childhood maltreatment-on inhibition-related brain function in individuals with PTSD versus trauma-exposed controls.Individuals with PTSD (n = 37) and trauma-exposed controls (n = 53) were recruited from the primary care waiting rooms of an urban public hospital in Atlanta, GA. Participants completed an inhibition task during fMRI, and reported childhood and adult traumatic experiences. The groups were matched for adult and child trauma load.We observed an interaction between childhood maltreatment severity and PTSD status in the rACC (P.05, corrected), such that maltreatment was negatively associated with inhibition-related rACC activation in the PTSD group, but did not influence rACC activation in the TC group. Rostral ACC activation was associated with inhibition-related task performance in the TC group but not the PTSD group, suggesting a possible contribution to stress resilience.Findings highlight individual differences in neural function following childhood trauma, and point to inhibition-related activation in rostral ACC as a risk factor for PTSD.
تدمد: 1520-6394
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::9454474581f237259ae093247d3fd63e
https://pubmed.ncbi.nlm.nih.gov/27062552
حقوق: OPEN
رقم الأكسشن: edsair.pmid..........9454474581f237259ae093247d3fd63e
قاعدة البيانات: OpenAIRE