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Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ

التفاصيل البيبلوغرافية
العنوان: Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ
المؤلفون: Jing, Yang, Yue, Sun, Fanxing, Xu, Weiwei, Liu, Toshihiko, Hayashi, Shunji, Hattori, Yuko, Ushiki-Kaku, Satoshi, Onodera, Shin-Ichi, Tashiro, Takashi, Ikejima
المصدر: Phytotherapy research : PTR. 33(4)
سنة النشر: 2018
مصطلحات موضوعية: Amyloid beta-Peptides, Down-Regulation, Apoptosis, Protective Agents, Reactive Nitrogen Species, Antioxidants, Peptide Fragments, Islet Amyloid Polypeptide, Rats, Up-Regulation, Receptors, Estrogen, Cytoprotection, Insulin-Secreting Cells, Silybin, Animals, Reactive Oxygen Species, Cells, Cultured, Signal Transduction
الوصف: Amylin and amyloid-β (Aβ) were found to induce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in rat pancreatic β-cell line, INS-1 cells, leading to cell death. In this study, we report on reciprocal relationship between the expression of estrogen receptors (ERs) α and β (ERα and ERβ) and generation of ROS/RNS in amylin/Aβ
تدمد: 1099-1573
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a2b84de5df8b93e6e56beb69fb00ac94
https://pubmed.ncbi.nlm.nih.gov/30729588
رقم الأكسشن: edsair.pmid..........a2b84de5df8b93e6e56beb69fb00ac94
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10991573