Insulin resistance and its consequences in chronic hepatitis C
| العنوان: | Insulin resistance and its consequences in chronic hepatitis C |
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| المؤلفون: | Kukla, Michał, Piotrowski, Damian, Waluga, Marek, Hartleb, Marek |
| المصدر: | Clinical and Experimental Hepatology |
| بيانات النشر: | Termedia Publishing House, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | adipokine, insulin resistance, fibrosis, steatosis, chronic hepatitis C, Review Article, liver |
| الوصف: | Chronic hepatitis C (CHC) is generally a slowly progressive disease, but some factors associated with rapid progression have been identified. Hepatitis C virus (HCV) may contribute to a broad spectrum of metabolic disturbances - namely, steatosis, insulin resistance (IR), increased prevalence of impaired glucose tolerance, type 2 diabetes mellitus (T2DM), lipid metabolism abnormalities and atherosclerosis. HCV can directly or indirectly cause both IR and steatosis, but it is still not resolved whether this viral impact bears the same prognostic value as the metabolic counterparts. As the population exposed to HCV ages, the morbidity due to this disease is increasing. The rising epidemic of obesity contributes to higher prevalence of IR and T2DM. Our understanding of the mutual association between both disease states continues to grow, but is still far from complete. This review briefly discusses the most probable mechanisms involved in IR development in the course of CHC. Molecular mechanisms for the direct and indirect influence of HCV on intracellular insulin signaling are described. Subsequently, the consequences of IR/T2DM for disease progression and management are summarized. |
| اللغة: | English |
| تدمد: | 2449-8238 2392-1099 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::ab2008d78fdcfaccffd2ae3401d026f2 http://europepmc.org/articles/PMC5421163 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........ab2008d78fdcfaccffd2ae3401d026f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24498238 23921099 |
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