التفاصيل البيبلوغرافية
العنوان:
Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAF
المؤلفون:
Eslam M H, Ali , Rania Farag A, El-Telbany , Mohammed S, Abdel-Maksoud , Usama M, Ammar , Karim I, Mersal , Seyed-Omar, Zaraei , Mohammed I, El-Gamal , Se-In, Choi , Kyung-Tae, Lee , Hee-Kwon, Kim , Kwan Hyi, Lee , Chang-Hyun, Oh
المصدر:
European journal of medicinal chemistry . 215
سنة النشر:
2020
مصطلحات موضوعية:
Proto-Oncogene Proteins B-raf , Molecular Structure , Imidazoles , Mitogen-Activated Protein Kinase 14 , Molecular Docking Simulation , Mice , Structure-Activity Relationship , Pyrimidines , Catalytic Domain , Cell Line, Tumor , Drug Design , Mutation , Animals , Humans , Drug Screening Assays, Antitumor , Protein Kinase Inhibitors , Cell Proliferation , Protein Binding
الوصف:
The synergistic effect of dual inhibition of serine/threonine protein kinases that are involved in the same signalling pathway of the diseases can exert superior biological benefits for treatment of these diseases. In the present work, a new series of (imidazol-5-yl)pyrimidine was designed and synthesized as dual inhibitors of BRAF
تدمد:
1768-3254
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae5d0db938e7dbaba26560fc27f076cc https://pubmed.ncbi.nlm.nih.gov/33601311
رقم الأكسشن:
edsair.pmid..........ae5d0db938e7dbaba26560fc27f076cc
قاعدة البيانات:
OpenAIRE
