Association between
| العنوان: | Association between |
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| المؤلفون: | Xiao-Qin, Wang, Yang, Li, Paul D, Terry, Wen-Jing, Kou, Yue, Zhang, Zhao-Zhao, Hui, Xiao-Han, Ren, Ming-Xu, Wang |
| المصدر: | World Journal of Gastrointestinal Oncology |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | rs907715, Intestinal metaplasia, Single nucleotide polymorphisms, Case Control Study, Interleukin-21 gene, Gastric precancerous lesions |
| الوصف: | BACKGROUND The single nucleotide polymorphisms of interleukin-21 (IL-21) gene were confirmed to be related to various diseases, but no studies have examined the possible role of IL-21 single nucleotide polymorphisms (SNPs) (rs907715, rs2221903, and rs12508721) in gastric precancerous lesions. AIM To explore the associations between SNPs of IL-21 gene (rs907715, rs2221903, and rs12508721) and gastric precancerous lesions in a Chinese population. METHODS Three SNPs of IL-21 were genotyped using polymerase chain reaction–ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern China. Gastric precancerous lesions were confirmed by endoscopic examination and categorized as non-atrophic gastritis, atrophic gastritis, and intestinal metaplasia. Descriptive statistic and logistic regression were used for data analyses. RESULTS IL-21 rs907715 genotype CC and C frequencies were higher in in patients with gastric precancerous lesions than in the controls (OR = 1.59, 95%CI: 1.06-2.38, P = 0.013; OR = 1.28, 95%CI: 1.01-2.22, P = 0.044, respectively) after adjusting for confounding factors. For SNP rs907715 in intestinal metaplasia patients, significant differences between cases and controls were observed in the frequencies of genotype CC and C (OR = 1.92, 95%CI: 1.24-2.98, P = 0.004; OR = 1.53, 95%CI: 1.04-2.24, P = 0.028, respectively); for non-atrophic gastritis and atrophic gastritis patients, the CC and C genotypes showed no significant association with risk in all models. No association between either rs2221903 or rs12508721 and gastric precancerous lesions was found in the present study. In the haplotype analysis, the TC haplotype (rs907715 and rs12508721) and TT haplotype (rs2221903 and rs907715) were more frequent in the case group than control group (P < 0.05). CONCLUSION Our findings indicate that SNP rs907715 of IL-21 gene is associated with gastric precancerous lesions. The TC haplotype (rs907715 and rs12508721) and TT haplotype (rs2221903 and rs907715) increased the risk of gastric precancerous lesions. If confirmed, these findings will shed light on the etiology of precancerous lesions. |
| تدمد: | 1948-5204 1250-8721 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::c13c87e5ed718b1fd82f198873d38992 https://pubmed.ncbi.nlm.nih.gov/32206179 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........c13c87e5ed718b1fd82f198873d38992 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19485204 12508721 |
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