التفاصيل البيبلوغرافية
العنوان:
Overcoming Preclinical Safety Obstacles to Discover (
المؤلفون:
Christopher, McBride , Lynnie, Trzoss , Davide, Povero , Milos, Lazic , Geza, Ambrus-Aikelin , Angelina, Santini , Rama, Pranadinata , Gretchen, Bain , Ryan, Stansfield , Jeffrey A, Stafford , James, Veal , Ryan, Takahashi , Justin, Ly , Shu, Chen , Liling, Liu , Marika, Nespi , Robert, Blake , Arna, Katewa , Tracy, Kleinheinz , Swathi, Sujatha-Bhaskar , Nandhini, Ramamoorthi , Jessica, Sims , Brent, McKenzie , Mark, Chen , Mark, Ultsch , Matthew, Johnson , Jeremy, Murray , Claudio, Ciferri , Steven T, Staben , Michael J, Townsend , Craig E, Stivala
المصدر:
Journal of medicinal chemistry . 65(21)
سنة النشر:
2022
مصطلحات موضوعية:
Sulfonamides , Macaca fascicularis , Inflammasomes , NLR Family, Pyrin Domain-Containing 3 Protein , Oxazines , Animals , Humans
الوصف:
Inappropriate activation of the NLRP3 inflammasome has been implicated in multiple inflammatory and autoimmune diseases. Herein, we aimed to develop novel NLRP3 inhibitors that could minimize the risk of drug-induced liver injury. Lipophilic ligand efficiency was used as a guiding metric to identify a series of 6,7-dihydro-5H-pyrazolo[5,1
تدمد:
1520-4804
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6c7a3ba99e95091c3e95ec62530fbf9 https://pubmed.ncbi.nlm.nih.gov/36279149
رقم الأكسشن:
edsair.pmid..........c6c7a3ba99e95091c3e95ec62530fbf9
قاعدة البيانات:
OpenAIRE
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