Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study
| العنوان: | Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study |
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| المؤلفون: | Stephen A, Metcalf, Peter B, Jones, Tanja, Nordstrom, Markku, Timonen, Pirjo, Mäki, Jouko, Miettunen, Erika, Jääskeläinen, Marjo-Riitta, Järvelin, Jan, Stochl, Graham K, Murray, Juha, Veijola, Golam M, Khandaker |
| المصدر: | Brain, Behavior, and Immunity |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, Risk, Adolescent, Inflammatory markers, behavioral disciplines and activities, C-reactive protein, Cohort Studies, Young Adult, International Classification of Diseases, mental disorders, Humans, Longitudinal Studies, Prospective Studies, Registries, Age of Onset, TNFα, tumour necrosis factor alpha, Finland, CDC, Centers for Disease Control and Prevention, Full-length Article, Psychiatric Status Rating Scales, AHA, American Heart Association, Psychotic disorders, Systemic inflammation, NAPLS, North American Prodrome Longitudinal Study, IL, interleukin, OR, odds ratio, ALSPAC, Avon Longitudinal Study of Parents and Children, Cross-Sectional Studies, NFBC, Northern Finland Birth Cohort, FHDR, Finnish Hospital Discharge Register, ICD-10, International Classification of Diseases, 10th revision, Schizophrenia, CRP, C-reactive protein, Female, Longitudinal study |
| الوصف: | Highlights • This is one of the first longitudinal studies of serum CRP & subsequent schizophrenia. • Elevated serum CRP in adolescence is associated with risk of adult schizophrenia. • The CRP-schizophrenia association is consistent with a dose-response relationship. Objective Meta-analyses of cross-sectional studies confirm an increase in circulating inflammatory markers during acute psychosis. Longitudinal studies are scarce but are needed to understand whether elevated inflammatory markers are a cause or consequence of illness. We report a longitudinal study of serum C-reactive protein (CRP) in adolescence and subsequent risk of schizophrenia and related psychoses in adulthood in the Northern Finland Birth Cohort 1986. Method Serum high-sensitivity CRP was measured at age 15/16 years in 6362 participants. ICD-10 diagnoses of schizophrenia and related psychoses were obtained from centralised hospital inpatient and outpatient registers up to age 27 years. Logistic regression calculated odds ratios (ORs) for psychotic outcomes associated with baseline CRP levels analysed as both continuous and categorical variables using American Heart Association criteria. Age, sex, body mass index, maternal education, smoking, and alcohol use were included as potential confounders. Results By age 27 years, 88 cases of non-affective psychosis (1.38%), of which 22 were schizophrenia (0.35%), were identified. Adolescent CRP was associated with subsequent schizophrenia. The adjusted OR for schizophrenia by age 27 years for each standard deviation (SD) increase in CRP levels at age 15/16 years was 1.25 (95% CI, 1.07–1.46), which was consistent with a linear, dose-response relationship (P-value for quadratic term 0.23). Using CRP as a categorical variable, those with high (>3 mg/L) compared with low ( |
| تدمد: | 1090-2139 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::cd01ca9b7d80fb7cb520667fc6f40484 https://pubmed.ncbi.nlm.nih.gov/27622678 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid..........cd01ca9b7d80fb7cb520667fc6f40484 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 10902139 |
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