Studies on the inhibition of rapid expulsion of Trichinella spiralis in rats

التفاصيل البيبلوغرافية
العنوان: Studies on the inhibition of rapid expulsion of Trichinella spiralis in rats
المؤلفون: R G, Bell, D D, McGregor, L S, Adams
المصدر: International archives of allergy and applied immunology. 69(1)
سنة النشر: 1982
مصطلحات موضوعية: Hypersensitivity, Immediate, Male, Prostaglandin Antagonists, Mice, Inbred Strains, Trichinellosis, Rats, Inbred F344, Rats, Cortisone, Mice, Rats, Inbred Lew, Rats, Inbred BN, Histamine H1 Antagonists, Animals, Serotonin Antagonists, Intestinal Diseases, Parasitic, Intestinal Mucosa, Gastrointestinal Motility, Anaphylaxis
الوصف: A variety of inhibitors was examined for their ability to interfere with the expression of rapid expulsion (RE) of challenge Trichinella spiralis infections in rats. Inhibitors of immediate hypersensitivity, prostaglandin release, peristalsis, or complement function, did not impair RE when administered to immune rats. Induction of intestinal anaphylaxis against T. spiralis or ovalbumin by passive serum transfer to intestinally primed rats (prior infection with Heligmosomoides polygyrus) or administration of the histamine liberator 48/80 also failed to stimulate RE. In contrast, irradiation or cortisone treatment 1, 3 or 5 days before challenge inhibited RE. We conclude that immediate hypersensitivity is not the terminal mediator of RE and plays a minor role or none at all. The effects of cortisone and irradiation suggest a major involvement by lymphoid cells in the RE reaction.
تدمد: 0020-5915
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cd8c758125c412ee98fc0a578fba2690
https://pubmed.ncbi.nlm.nih.gov/6125479
رقم الأكسشن: edsair.pmid..........cd8c758125c412ee98fc0a578fba2690
قاعدة البيانات: OpenAIRE