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Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis

التفاصيل البيبلوغرافية
العنوان: Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis
المؤلفون: Nerella, Sridhar Goud, Venkatesh, Pooladanda, K, Muni Chandra, P S, Lakshmi Soukya, Ravi, Alvala, Pardeep, Kumar, Chandana, Nagaraj, Rose, Dawn Bharath, Insaf A, Qureshi, Chandraiah, Godugu, Mallika, Alvala
المصدر: Bioorganic chemistry. 102
سنة النشر: 2020
مصطلحات موضوعية: Fluorine Radioisotopes, Lung Neoplasms, Dose-Response Relationship, Drug, Galectin 1, Molecular Structure, Antineoplastic Agents, Apoptosis, Triazoles, Structure-Activity Relationship, Drug Design, Tumor Cells, Cultured, Humans, Benzimidazoles, Drug Screening Assays, Antitumor, Cell Proliferation
الوصف: In this study, we have synthesized a new series of benzimidazole-triazole hybrids as galectin-1 (gal-1) mediated apoptosis-inducing agents, and evaluated for their potential anticancer activity against a panel of human cancer cell lines viz. breast cancer (MCF-7 and MDA-MB-231) lung cancer (A-549 and NCI-H460), and human keratinocyte cancer (HaCaT), using MTT assay. The target compound 7c exhibited an excellent growth inhibition against lung cancer (A-549 and NCI-H460) cells with an IC
تدمد: 1090-2120
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d648eba98535490719f2d12bbb92e9f6
https://pubmed.ncbi.nlm.nih.gov/32738568
رقم الأكسشن: edsair.pmid..........d648eba98535490719f2d12bbb92e9f6
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10902120