The present paper addresses the changes of clinical pattern and etiological factors in uveitis in China. Behçet's disease and Vogt-Koyanagi-Harada syndrome have been shown to be the two most common and the most severe sight-threatening uveitis entities in China. Uveitis or endophthalmitis caused by tuberculosis, syphilis, fungi and acquired immune deficiency syndrome has increased in frequency during recent years. Masquerade syndrome seen in intraocular-central nervous system lymphoma, retinoblastoma and metastases of cancers to the eye is not a rare disease.