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Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli

التفاصيل البيبلوغرافية
العنوان: Development of local anesthetic drug delivery system by administration of organo-silica nanoformulations under ultrasound stimuli
المؤلفون: Rong-Qin, Qi, Wei, Liu, Duan-Yu, Wang, Fan-Qing, Meng, Hong-Ying, Wang, Hai-Yan, Qi
المصدر: Drug Delivery
article-version (VoR) Version of Record
سنة النشر: 2020
مصطلحات موضوعية: Male, Neurons, Chitosan, Drug Carriers, Chemistry, Pharmaceutical, Fibroblasts, silica nanoparticles, Silicon Dioxide, Rats, Rats, Sprague-Dawley, Drug Liberation, biocompatibility, Drug Stability, Ultrasonic Waves, anesthetic, drug delivery, Animals, Nanoparticles, Ropivacaine, Anesthetics, Local, Research Article
الوصف: The development of local anesthetic (LA) system is the application of commercial drug for the pain management that indorses the reversible obstructive mechanism of neural transmission through preventing the innervation process in human peripheral nerves. Ropivacaine (RV) is one of the greatest frequently used LA s with the actions of long-lasting and low-toxicity for the post-operative pain management. In this work, we have approached novel design and development of glycosylated chitosan (GCS) encapsulated mesoporous silica nanoparticles (GCS-MONPs)-based nano-scaffold for sustainable distributions and controlled/supported arrival of stacked RV for targeting sites, which can be activated by either outer ultrasound activating to discharge the payload, foundation on-request and dependable analgesia. The structural and morphology analyses result established that prepared nano-formulations have successful molecular interactions and RV loaded spherical morphological structures. The drug release profile of developed nanostructure with ultrasound-activation has been achieved 50% of drug release in 2 h and 90% of drug release was achieved in 12 h, which displays more controlled release when compared to free RV solution. The in vitro cell compatibility analysis exhibited GCS-MONPs with RV has improved neuron cell survival rates when compared to other samples due to its porous surface and suitable biopolymer proportions. The analysis of ex vitro and in vivo pain relief analysis demonstrated treated animal models have high compatibility with GCS-MONPs@RV, which was confirmed by histomorphology. This developed MONPs based formulations with ultrasound-irradiation gives a prospective technique to clinical agony the board through on-request and dependable help with discomfort.
تدمد: 1521-0464
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e0455169d36f7891c611ed8db4abddd1
https://pubmed.ncbi.nlm.nih.gov/33342323
حقوق: OPEN
رقم الأكسشن: edsair.pmid..........e0455169d36f7891c611ed8db4abddd1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15210464