to explore possible transgeneration effects in the rats offspring of the first generation of parents subject ed to the combined effects of N stearoylethanolamine (NSE) and external exposure.Materials and metods. In the first generation rats of both sexes born to parents who have experienced the combined influence of ionizing radiation at a dose of 2.0 Gy and NSE a daily dose of 50.0 mg/kg, administered before or after exposure indicators of pro and antioxidant systems (the concentration of TBA reactive products, catalase and glu tathione peroxidase activity in plasma) were defined, concentrations of sex hormones testosterone and estradiol and nitrite anion were studied.Irradiation of parents caused a three fold reduction of testosterone in the blood plasma of males progeny, increased activity of catalase in plasma of female offsprings, as well as significantly increased the concentration of protein in the offsprings' blood plasma of both sexes. Introduction of NSE to parents before exposure caused the acti vation of lipid peroxidation in plasma of both sexes offsprings' against the background of a trustworthy decrease in activity of antioxidant enzymes (catalase and glutathione peroxidase), however, prevented a sharp reduction of testosterone content in the blood plasma of males offsprings, conditioned by the influence of radiation on the body of their parents. NSE introduction to parents after exposure caused no significant violations of pro/ antioxidant bal ance in the body of both sexes progeny, but did not eliminate the negative impact of parental exposure to testos terone levels in male offsprings.The transgeneration impact of NSE is manifested by radio sensitizing properties in the first generation offsprings in case of application to parents before irradiation.Meta: vyvchyty mozhlyvi transgeneratsiy̆ni efekty u nashchadkiv pershogo pokolinnia shchuriv v umovakh kombinovanogo vplyvu N stearoïletanolaminu (NSE) ta zovnishn'ogo oprominennia ïkh bat'kiv.Materialy i metody. U nashchadkiv pershogo pokolinnia shchuriv obokh statey̆ vid bat'kiv, iaki zaznaly kombinovanoï diï ionizuiuchogo vyprominennia v dozi 2,0 Gr ta NSE v dozi 50,0 mg/kg, vvedenogo do abo pislia oprominennia, vyznacha ly pokaznyky pro ta antyoksydantnoï system (kontsentratsiiu TBK reaguiuchykh produktiv, aktyvnosti katalazy, glutationperoksydazy v plazmi krovi), doslidzhuvaly kontsentratsiiu statevykh gormoniv testosteronu i estradiolu, a takozh kontsentratsiiu nitryt anionu.Rezul'taty. Oprominennia bat'kiv sprychynialo tryrazove znyzhennia vmistu testosteronu v plazmi krovi na shchadkiv samtsiv ta zrostannia aktyvnosti katalazy v plazmi krovi nashchadkiv samyts', a takozh virogidne zbil'shennia kontsentratsiï proteïnu v plazmi krovi nashchadkiv obokh statey̆. Vvedennia NSE bat'kam do oprominennia vyklykalo aktyvatsiiu protsesiv POL u plazmi krovi nashchadkiv obokh statey̆ na tli virogidnogo znyzhennia aktyvnosti fermentiv antyoksydantnogo zakhystu (katalazy ta glutationperoksydazy), odnak zapobigalo rizkomu znyzhenniu vmistu tes tosteronu v plazmi krovi nashchadkiv samtsiv, obumovlenomu diieiu oprominennia na organizm bat'kiv. Vvedennia NSE bat'kam pislia oprominennia ne sprychynialo istotnykh porushen' pro/antyoksydantnoï rivnovagy v organizmi na shchadkiv obokh statey̆, prote ne usuvalo negatyvnogo vplyvu oprominennia bat'kiv na riven' testosteronu u na shchadkiv samtsiv.Vysnovok. Transgeneratsiy̆nyy̆ vplyv NSE, proiavliaiet'sia radiosensybilizuiuchymy vlastyvostiamy v nashchadkiv per shogo pokolinnia u vypadku y̆ogo zastosuvannia do oprominennia bat'kiv.
