Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia
| العنوان: | Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia |
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| المؤلفون: | Fanti, S., Barbieri, C., Sarno, S., Sevini, F., Vianello, D., Tamm, E., Metspalu, E., van Oven, M., Hübner, A., Sazzini, M., Franceschi, C., Pettener, D., Luiselli, D. |
| المساهمون: | De Fanti, Sara, Barbieri, Chiara, Sarno, Stefania, Sevini, Federica, Vianello, Dario, Tamm, Erika, Metspalu, Ene, van Oven, Manni, Hübner, Alexander, Sazzini, Marco, Franceschi, Claudio, Pettener, Davide, Luiselli, Donata, Genetic Identification |
| المصدر: | PLoS ONE, Vol 10, Iss 12, p e0144391 (2015) PLoS ONE PLoS One (print), 10(12). Public Library of Science PLoS One |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Geography, Molecular Sequence Data, lcsh:R, Genetic Variation, lcsh:Medicine, Mitochondrial haplogroups, Italian peninsula, Epigravettian, Phylogeography, BEAST, DNA, Mitochondrial, White People, Mitochondria, Europe, Phylogeography, Genetics, Population, Haplotypes, Ethnicity, Humans, Cell Lineage, lcsh:Q, lcsh:Science, Research Article |
| الوصف: | Genetic signatures from the Paleolithic inhabitants of Eurasia can be traced from the early divergent mitochondrial DNA lineages still present in contemporary human populations. Previous studies already suggested a pre-Neolithic diffusion of mitochondrial haplogroup HV*(xH, V) lineages, a relatively rare class of mtDNA types that includes parallel branches mainly distributed across Europe and West Asia with a certain degree of structure. Up till now, variation within haplogroup HV was addressed mainly by analyzing sequence data from the mtDNA control region, except for specific sub-branches, such as HV4 or the widely distributed haplogroups H and V. In this study, we present a revised HV topology based on full mtDNA genome data, and we include a comprehensive dataset consisting of 316 complete mtDNA sequences including 60 new samples from the Italian peninsula, a previously underrepresented geographic area. We highlight points of instability in the particular topology of this haplogroup, reconstructed with BEAST-generated trees and networks. We also confirm a major lineage expansion that probably followed the Late Glacial Maximum and preceded Neolithic population movements. We finally observe that Italy harbors a reservoir of mtDNA diversity, with deep-rooting HV lineages often related to sequences present in the Caucasus and the Middle East. The resulting hypothesis of a glacial refugium in Southern Italy has implications for the understanding of late Paleolithic population movements and is discussed within the archaeological cultural shifts occurred over the entire continent. |
| وصف الملف: | ELETTRONICO; application/pdf; application/zip |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::061c83a388f7bacd186d5be038bc6170 http://hdl.handle.net/11585/524972 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....061c83a388f7bacd186d5be038bc6170 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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