Cardiovascular status after Kawasaki disease in the UK
| العنوان: | Cardiovascular status after Kawasaki disease in the UK |
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| المؤلفون: | Shah, V, Christov, G, Mukasa, T, Brogan, KS, Wade, A, Eleftheriou, D, Levin, M, Tulloh, RM, Almeida, B, Dillon, MJ, Marek, J, Klein, N, Brogan, PA |
| المصدر: | Heart |
| بيانات النشر: | BMJ Publishing Group, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | EXPRESSION, Adult, Male, Cardiac & Cardiovascular Systems, CIRCULATING ENDOTHELIAL-CELLS, SURFACE, Adolescent, SYSTEMIC VASCULITIS, CHILDREN, Coronary Artery Disease, Mucocutaneous Lymph Node Syndrome, Pulse Wave Analysis, 1102 Cardiovascular Medicine And Haematology, Carotid Intima-Media Thickness, Risk Assessment, Young Adult, Risk Factors, mental disorders, Humans, cardiovascular diseases, Child, Retrospective Studies, Science & Technology, Incidence, Great Britain, nutritional and metabolic diseases, DYSFUNCTION, United Kingdom, Cardiovascular System & Hematology, GIANT CORONARY ANEURYSMS, Cardiovascular Diseases, Child, Preschool, YOUNG, Cardiovascular System & Cardiology, RISK-FACTORS, cardiovascular system, Female, HEALTH, Endothelium, Vascular, Life Sciences & Biomedicine, Biomarkers, Follow-Up Studies |
| الوصف: | Objective Kawasaki disease (KD) is an acute vasculitis that causes coronary artery aneurysms (CAA) in young children. Previous studies have emphasised poor long-term outcomes for those with severe CAA. Little is known about the fate of those without CAA or patients with regressed CAA. We aimed to study long-term cardiovascular status after KD by examining the relationship between coronary artery (CA) status, endothelial injury, systemic inflammatory markers, cardiovascular risk factors (CRF), pulse-wave velocity (PWV) and carotid intima media thickness (cIMT) after KD. Methods Circulating endothelial cells (CECs), endothelial microparticles (EMPs), soluble cell-adhesion molecules cytokines, CRF, PWV and cIMT were compared between patients with KD and healthy controls (HC). CA status of the patients with KD was classified as CAA present (CAA+) or absent (CAA−) according to their worst-ever CA status. Data are median (range). Results Ninety-two KD subjects were studied, aged 11.9 years (4.3–32.2), 8.3 years (1.0–30.7) from KD diagnosis. 54 (59%) were CAA−, and 38 (41%) were CAA+. There were 51 demographically similar HC. Patients with KD had higher CECs than HC (p=0.00003), most evident in the CAA+ group (p=0.00009), but also higher in the CAA− group than HC (p=0.0010). Patients with persistent CAA had the highest CECs, but even those with regressed CAA had higher CECs than HC (p=0.011). CD105 EMPs were also higher in the KD group versus HC (p=0.04), particularly in the CAA+ group (p=0.02), with similar findings for soluble vascular cell adhesion molecule 1 and soluble intercellular adhesion molecule 1. There was no difference in PWV, cIMT, CRF or in markers of systemic inflammation in the patients with KD (CAA+ or CAA−) compared with HC. Conclusions Markers of endothelial injury persist for years after KD, including in a subset of patients without CAA. |
| اللغة: | English |
| تدمد: | 1468-201X 1355-6037 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::134d132a9dabad88cc73431f38134fee http://europepmc.org/articles/PMC4621377 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....134d132a9dabad88cc73431f38134fee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468201X 13556037 |
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