First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy
| العنوان: | First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy |
|---|---|
| المؤلفون: | Schaefer, P. W., LUCA ROCCATAGLIATA, Ledezma, C., Hoh, B., Schwamm, L. H., Koroshetz, W., Gonzalez, R. G., Lev, M. H. |
| المصدر: | AJNR Am J Neuroradiol Scopus-Elsevier |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Male, Blood Volume, Iohexol, Brain, Contrast Media, Cerebral Infarction, Middle Aged, Brain Ischemia, Stroke, Fibrinolytic Agents, Injections, Intra-Arterial, Tissue Plasminogen Activator, Cerebrovascular Circulation, cardiovascular system, Humans, Female, Thrombolytic Therapy, Letters, Tomography, Spiral Computed, Blood Flow Velocity, circulatory and respiratory physiology, Aged |
| الوصف: | BACKGROUND AND PURPOSE: The purpose of this study was to determine whether, in acute stroke patients treated with intra-arterial (IA) recanalization therapy, CT perfusion (CTP) can distinguish ischemic brain tissue destined to infarct from that which will survive. METHODS: Dynamic CTP was obtained in 14 patients within 8 hours of stroke onset, before IA therapy. Initial quantitative cerebral blood volume (CBV) and flow (CBF) values were visually segmented and normalized in the “infarct core” (region 1: reduced CBV and CBF, infarction on follow-up), “penumbra that infarcts” (region 2: normal CBV, reduced CBF, infarction on follow-up), and “penumbra that recovers” (region 3: normal CBV, reduced CBF, normal on follow-up). Normalization was accomplished by dividing the ischemic region of interest value by that of a corresponding, contralateral, uninvolved region, which resulted in CBV and CBF “ratios.” Separate CBV and CBF values were obtained in gray matter (GM) and white matter (WM). RESULTS: Mean CBF ratios for regions 1, 2, and 3 were 0.19 ± 0.06, 0.34 ± 0.06, and 0.46 ± 0.09, respectively (all P < .001). Mean CBV ratios for regions 1, 2, and 3 were similarly distinct (all P < .05). Absolute CBV and CBF values for regions 2 and 3 were not significantly different. All regions with CBF ratio 0.44 infarcted. GM versus WM CBF and CBV values were significantly different for region 2 compared with region 3 (P < .05). CONCLUSIONS: In acute stroke patients, quantitative CTP can distinguish ischemic tissue likely to infarct from that likely to survive. |
| تدمد: | 0195-6108 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::151569e8080e59e0b6119d454142d105 https://pubmed.ncbi.nlm.nih.gov/16927470 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....151569e8080e59e0b6119d454142d105 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01956108 |
|---|