Viral RNA Metagenomics of
| العنوان: | Viral RNA Metagenomics of |
|---|---|
| المؤلفون: | Zakham, Fathiah, Albalawi, Aishah E., Alanazi, Abdullah D., Phuoc Truong Nguyen, Alouffi, Abdulaziz S., Alaoui, Altaf, Sironen, Tarja, Smura, Teemu, Vapalahti, Olli |
| المساهمون: | Helsinki One Health (HOH), Veterinary Biosciences, Department of Virology, Medicum, Faculty of Pharmacy, Viral Zoonosis Research Unit, Emerging Infections Research Group, HUSLAB, HUS Diagnostic Center, Veterinary Microbiology and Epidemiology, Olli Pekka Vapalahti / Principal Investigator |
| المصدر: | Viruses Viruses, Vol 13, Iss 1396, p 1396 (2021) Volume 13 Issue 7 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | TAMDY, 11832 Microbiology and virology, COMPLEX, Camelus, Hyalomma dromedarii, Virome, viruses, Saudi Arabia, virome analysis, dromedary camels, Microbiology, QR1-502, Article, Ticks, province of Makkah, arboviruses, Tick-Borne Diseases, parasitic diseases, Viruses, Animals, Humans, RNA, Viral, HEMORRHAGIC-FEVER VIRUS, Metagenomics |
| الوصف: | Arthropod-borne infections are a medical and economic threat to humans and livestock. Over the last three decades, several unprecedented viral outbreaks have been recorded in the Western part of the Arabian Peninsula. However, little is known about the circulation and diversity of arthropod-borne viruses in this region. To prepare for new outbreaks of vector-borne diseases, it is important to detect which viruses circulate in each vector population. In this study, we used a metagenomics approach to characterize the RNA virome of ticks infesting dromedary camels (Camelus dromedaries) in Makkah province, Saudi Arabia. Two hundred ticks of species Hyalomma dromedarii (n = 196) and Hyalomma impeltatum (n = 4) were collected from the Alkhurma district in Jeddah and Al-Taif city. Virome analysis showed the presence of several tick-specific viruses and tick-borne viruses associated with severe illness in humans. Some were identified for the first time in the Arabian Peninsula. The human disease-associated viruses detected included Crimean Congo Hemorrhagic fever virus and Tamdy virus (family Nairoviridae), Guertu virus (family Phenuiviridae), and a novel coltivirus that shares similarities with Tarumizu virus, Tai forest reovirus and Kundal virus (family Reoviridae). Furthermore, Alkhurma hemorrhagic virus (Flaviviridae) was detected in two tick pools by specific qPCR. In addition, tick-specific viruses in families Phenuiviridae (phleboviruses), Iflaviridae, Chuviridae, Totiviridae and Flaviviridae (Pestivirus) were detected. The presence of human pathogenetic viruses warrants further efforts in tick surveillance, xenosurveillence, vector control, and sero-epidemiological investigations in human and animal populations to predict, contain and mitigate future outbreaks in the region. |
| وصف الملف: | application/pdf |
| تدمد: | 1999-4915 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::154a42bdf64f2024d5637743c874e1f4 https://pubmed.ncbi.nlm.nih.gov/34372602 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....154a42bdf64f2024d5637743c874e1f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
|---|