OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more
| العنوان: | OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more |
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| المؤلفون: | Altenhoff, A.M., Train, C.M., Gilbert, K.J., Mediratta, I., Mendes de Farias, T., Moi, D., Nevers, Y., Radoykova, H.S., Rossier, V., Warwick Vesztrocy, A., Glover, N.M., Dessimoz, C. |
| المصدر: | Nucleic Acids Research Nucleic acids research, vol. 49, no. D1, pp. D373-D379 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Internet, Genome, SARS-CoV-2, AcademicSubjects/SCI00010, COVID-19, Chromosome Mapping, Synteny, Evolution, Molecular, Gene Ontology, Species Specificity, Databases, Genetic, Gene Order, Animals, Humans, Database Issue, Algorithms, COVID-19/epidemiology, COVID-19/prevention & control, COVID-19/virology, Gene Order/genetics, Genome/genetics, Pandemics, Phylogeny, SARS-CoV-2/genetics, SARS-CoV-2/physiology |
| الوصف: | OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https://omabrowser.org. |
| وصف الملف: | application/pdf |
| تدمد: | 1362-4962 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22e5e19ebf828fc4baf6ebc11c9abe24 https://pubmed.ncbi.nlm.nih.gov/33174605 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....22e5e19ebf828fc4baf6ebc11c9abe24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 |
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