Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats
| العنوان: | Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats |
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| المؤلفون: | Hakimizadeh, E., Arababadi, M. K., Ali Shamsizadeh, Allahtavakoli, M., Rezvani, M. E., Roohbakhsh, A. |
| المصدر: | Iranian Journal of Medical Sciences, Vol 39, Iss 3, Pp 261-267 (2014) Iranian Journal of Medical Sciences Scopus-Elsevier |
| بيانات النشر: | Shiraz University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | lcsh:R5-920, ● Vanilloid receptor subtype 1 ● CA1 region ● Amygdala ● Morphine ● Rats, Morphine, nervous system, CA1 region, Original Article, Amygdala, lcsh:Medicine (General), Vanilloid receptor subtype 1, Rats |
| الوصف: | Background: Chronic use of opioids usually results in physical dependence. The underlying mechanisms for this dependence are still being evaluated. Transient receptor potential vanilloid type 1 (TRPV1) are important receptors of pain perception. Their role during opioid dependence has not been studied well. The aim of this study was to evaluate the effect of morphine-dependence on the expression of TRPV1 receptors in the amygdala and CA1 region of the hippocampus. Methods: This study used four groups of rats. Two groups of rats (morphine and morphine+naloxone) received morphine based on the following protocol: 10 mg/kg (twice daily, 3 days) followed by 20, 30, 40 and 50 mg/kg (twice daily), respectively, for 4 consecutive days. Another group received vehicle (1 ml/kg) instead of morphine given using the same schedule. The morphine+naloxone group of rats additionally received naloxone (5 mg/kg) at the end of the protocol. The control group rats received no injections or intervention. The amygdala and CA1 regions of the morphine, saline-treated and intact animals were isolated and prepared for real-time PCR analysis. Results: Administration of naloxone induced withdrawal signs in morphine-treated animals. The results showed a significant decrease in TRPV1 gene expression in the amygdala (P |
| اللغة: | English |
| تدمد: | 1735-3688 0253-0716 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::76487370bacc075fccc6cd15b6b34fb8 http://ijms.sums.ac.ir/index.php/IJMS/article/view/826/220 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....76487370bacc075fccc6cd15b6b34fb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17353688 02530716 |
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