Beta-catenin and surviving expression in keratocystic odontogenic tumor (KCOT). A comparative immunohistochemical study in primary, recurrent and nevoid basal cell carcinoma syndrome (NBCCS)-associated lesions
| العنوان: | Beta-catenin and surviving expression in keratocystic odontogenic tumor (KCOT). A comparative immunohistochemical study in primary, recurrent and nevoid basal cell carcinoma syndrome (NBCCS)-associated lesions |
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| المؤلفون: | Leonardi, R., Matthews, J. B., Loreto, C., Musumeci, G., giuseppina campisi, Lo Muzio, L., Dos Santos, J. N., Pastorino, L., Bufo, P., Pannone, G. |
| المساهمون: | Leonardi, R, Matthews, JB, Loreto, C, Musumeci, G, Campisi, G, Lo Muzio, L, dos Santos, JN, Pastorino, L, Bufo, P, Pannone, G |
| المصدر: | Scopus-Elsevier Publons DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname |
| بيانات النشر: | F HERNANDEZ, PLAZA FUENSANTA 2-7 C, 30008 MURCIA, SPAIN, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Histology, Adolescent, Survivin, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Settore MED/50 - Scienze Tecniche Mediche Applicate, Apoptosis, Odontogenic Tumors, ß-catenin, NBCCS, Inhibitor of Apoptosis Proteins, Settore MED/29 - Chirurgia Maxillofacciale, Young Adult, Recurrence, Settore MED/28 - Malattie Odontostomatologiche, Humans, beta Catenin, Cell Cycle, NBCCS, ß-catenin, Survivin, KCOT, Basal Cell Nevus Syndrome, Middle Aged, Immunohistochemistry, Gene Expression Regulation, Neoplastic, stomatognathic diseases, KCOT, 2734, Keratins, Female |
| الوصف: | Aim: To determine the epithelial expression of ß-catenin and survivin in sporadic (primary, and recurrent) and nevoid basal cell carcinoma syndrome (NBCCS) keratocystic odontogenic tumour (KCOT) in order to assess activation of the ß-catenin pathway and evidence of apoptotic inhibition, processes that may contribute to the known differences in their biological behaviour. Materials and Methods: Sections from 40 cases of KCOT (19 sporadic/primary; 9 sporadic/recurrent and 12 NBCCS-associated) were immunohistochemically stained for ß-catenin and survivin. The extent and intensity of immunoreactivity within the lining epithelium was assessed, using semi-quantitative scales, independently by two pathologists who were blinded to the clinical-pathological data. Data were analysed using Kruskal-Wallis test and, for pair-wise comparisons, Mann-Whitney test with Bonferroni correction. Results: All cystic epithelial linings stained for ß- catenin and survivin but there were differences in the pattern and intensity of staining among KCOT types. Sporadic primary KCOT showed weaker staining for ß- catenin (P=0.0003) and survivin (P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9d25da590c0dc84323d91171b16a92d http://hdl.handle.net/10447/95623 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....a9d25da590c0dc84323d91171b16a92d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |