Quantitative assessment of interim PET in Hodgkin lymphoma: An evaluation of the qPET method in adult patients in the RAPID trial
| العنوان: | Quantitative assessment of interim PET in Hodgkin lymphoma: An evaluation of the qPET method in adult patients in the RAPID trial |
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| المؤلفون: | Georgi, Thomas W., Kurch, Lars, Hasenclever, Dirk, Warbey, Victoria S., Pike, Lucy, Radford, John, Sabri, Osama, Kluge, Regine, Barrington, Sally F. |
| المصدر: | PLoS ONE Georgi, T W, Kurch, L, Hasenclever, D, Warbey, V S, Pike, L, Radford, J, Sabri, O, Kluge, R & Barrington, S F 2020, ' Quantitative assessment of interim PET in Hodgkin lymphoma : An evaluation of the qPET method in adult patients in the RAPID trial ', PLoS ONE, vol. 15, no. 4, e0231027 . https://doi.org/10.1371/journal.pone.0231027 PLoS ONE, Vol 15, Iss 4, p e0231027 (2020) |
| بيانات النشر: | Public Library of Science, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Clinical Oncology, Adult, Male, Adolescent, Lymphoma, Imaging Techniques, Science, Cancer Treatment, Radiation Therapy, Neuroimaging, Research and Analysis Methods, Pathology and Laboratory Medicine, Pediatrics, Diagnostic Radiology, Hematologic Cancers and Related Disorders, Cancer Chemotherapy, Young Adult, Signs and Symptoms, Drug Therapy, Diagnostic Medicine, Positron Emission Tomography Computed Tomography, Antineoplastic Combined Chemotherapy Protocols, Medicine and Health Sciences, Chemotherapy, Humans, Tomography, Aged, Manchester Cancer Research Centre, Pharmaceutics, ResearchInstitutes_Networks_Beacons/mcrc, Radiology and Imaging, Cancers and Neoplasms, Biology and Life Sciences, Hematology, Middle Aged, Hodgkin Disease, Oncology, Lesions, Medicine, Lymphomas, Female, Clinical Medicine, Positron Emission Tomography, Research Article, Neuroscience |
| الوصف: | AimqPET is a quantitative method used to assess FDG-PET response in lymphoma. qPET was developed using 898 scans from children with Hodgkin Lymphoma (HL) in the EuroNet-PHL-C1 (C1) trial. The aim of this study was to determine if qPET could be applied as an alternative response method in adults in the RAPID trial.MethodsPET-CT scans performed after 3 cycles of ABVD in RAPID were re-evaluated by an independent reader, blinded to PET results and outcome in RAPID. All initially involved regions were assessed visually and by qPET. The distribution of qPET measurements was compared for RAPID and C1 patients. Previously published qPET thresholds corresponding to visual DS (vDS) of 1-5 in C1 were used to derive quantitative DS (qDS) for RAPID patients.ResultsPET-CT scans were available for 450 patients from RAPID. vDS were 1 (171 scans), 2 (153 scans), 3 (72 scans), 4 (31 scans) and 5 (23 scans) respectively. The distribution of qPET values was similar to C1 patients, with a unimodal 'normal' distribution and a long tail to the right, suggestive of favorable response in the majority and less favorable response in the minority with outlying values. qPET thresholds from C1 applied in RAPID patients gave 86% concordance for vDS and qDS. There was 97% concordance for complete metabolic response (CMR; DS 1-3) vs. no-CMR using the Lugano classification.ConclusionqPET which was developed in pediatric patients receiving more intensive OEPA chemotherapy, was a suitable quantitative method for assessing response in adult patients treated with ABVD in a response-adapted setting in the RAPID trial. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::af73a011a2725e2b5abe99a8a1ea611b http://europepmc.org/articles/PMC7117720 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....af73a011a2725e2b5abe99a8a1ea611b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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