Monocyte subtype counts are associated with 10-year cardiovascular disease risk as determined by the Framingham Risk Score among subjects of the LIFE-Adult study
| العنوان: | Monocyte subtype counts are associated with 10-year cardiovascular disease risk as determined by the Framingham Risk Score among subjects of the LIFE-Adult study |
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| المؤلفون: | Samira Zeynalova, Karolin Bucksch, Markus Scholz, Maryam Yahiaoui-Doktor, Melanie Gross, Markus Löffler, Susanne Melzer, Attila Tárnok |
| المساهمون: | Publica |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 3, p e0247480 (2021) |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Cardiovascular Medicine, coronary heart disease, monocyte counts, Framingham Risk Score, LIFE-Adult study, Biochemistry, Vascular Medicine, Carotid Intima-Media Thickness, Monocytes, Cohort Studies, White Blood Cells, Leukocyte Count, Medical Conditions, Endocrinology, Spectrum Analysis Techniques, Animal Cells, Risk Factors, Germany, Medicine and Health Sciences, Odds Ratio, Coronary Heart Disease, medical risk factors, Ultrasonography, Middle Aged, Flow Cytometry, Lipids, Plaque, Atherosclerotic, Cholesterol, Carotid Arteries, Cardiovascular Diseases, Spectrophotometry, Medicine, Female, Durchflusszytometrie, Cytophotometry, Cellular Types, Research Article, Adult, Endocrine Disorders, Science, Immune Cells, Immunology, Cell Enumeration Techniques, Cardiology, Research and Analysis Methods, Diabetes Mellitus, Humans, Lymphocyte Count, ddc:610, Blood Cells, Biology and Life Sciences, Cell Biology, Cardiovascular Disease Risk, Metabolic Disorders, Biomarkers |
| الوصف: | Coronary heart disease, an inflammatory disease, is the leading cause of death globally. White blood cell counts (including monocytes) are easily available biomarkers of systemic inflammation. Monocyte subtypes can be measured by flow cytometry and classified into classical (CD14high, CD16neg), intermediate (CD14high, CD16+) and non-classical (CD14+, CD16high) with distinct functional properties. The goal of this study was to investigate the association of monocyte total count and its subtypes with cardiovascular risk groups defined by the Framingham Risk Score, which is used to estimate the 10-year risk of developing myocardial infarction or predict mortality following coronary heart disease. We also aimed to investigate whether monocyte counts are associated with relevant cardiovascular risk factors not included in the Framingham Risk Score, such as carotid atherosclerotic plaque and intima-media thickness. Our data came from the LIFE-Adult study, a population-based cohort study of 10,000 randomly selected participants in Leipzig, Germany. Data was gathered using self-administered questionnaires and physical examinations. Carotid plaques and intima-media thickness were measured using carotid artery sonography. Monocyte subtypes in blood were determined by 10-color flow cytometry for a total of 690 individuals. In a multivariate regression analysis adjusting for the risk factors BMI, intima-media thickness, presence of carotid plaques and diabetes mellitus, monocyte subtypes and total count were found to be significantly associated with the dichotomized Framingham Risk Score (≥10% versus |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bfdbd6b30fd6a7969fb19f428adced84 https://ul.qucosa.de/id/qucosa:78027 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.pmid.dedup....bfdbd6b30fd6a7969fb19f428adced84 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |