Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress
التفاصيل البيبلوغرافية
العنوان:
Peculiarity of changes of peripheral blood hematological indices in rats under N-stearoilethanolamine administration conditioned by combined effects of ionizing radiation and stress
Objective - to investigate the peculiarities of peripheral blood indices changes in rats under the N-stearoiletanolamine treatment before and after combined effects of ionizing radiation and stress.hematological, statistical.Per oral administration of NSE (10,0 mg / kg) before and after the combined effects of single whole-body irradiation (6.0 Gy) and emotionally-algesic stress (foot-shock) leads to reduction in the number of circulating peripheral blood cells, increasing signs of damage of the hematopoietic system with accelerated exhaustion processes. Conclusions. NSE administration (10,0 mg / kg) in rats under the combined influence of ionizing radiation (6 Gy) and emotionally-algesic stress slows down the course of regenerative processes and accelerates the depletion of the hematopoietic system, proving for its radiosensitizing effects.Meta – vyvchyty osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv za umov vvedennja N-stearoi'letanolaminu (NSE) do ta pislja kombinovanoi' dii' ionizujuchogo vyprominjuvannja ta emocijno-bol'ovogo stresu. Metody: gematologichni, statystychni. Rezul'taty. Na osnovi kil'kisnyh i jakisnyh zmin gematologichnyh pokaznykiv peryferychnoi' krovi vstanovleno, shho vvedennja shhuram NSE (10,0 mg/kg) do ta pislja kombinovanogo vplyvu odnorazovogo total'nogo oprominennja (6,0 Gr) i emocijno-bol'ovogo stresu (fut-shok) pryzvodyt' do znyzhennja kil'kosti cyrkuljujuchyh klityn peryferychnoi' krovi, zbil'shennja oznak urazhennja krovotvornoi' systemy z pryskorennjam procesiv vysnazhennja. Vysnovok. Vvedennja shhuram NSE (10,0 mg/kg) v umovah kombinovanogo vplyvu ionizujuchogo vyprominjuvannja (6,0 Gr) i emocijno-bol'ovogo stresu spovil'njuje perebig vidnovnyh procesiv i pryskorjuje procesy vysnazhennja u krovotvornij systemi, shho svidchyt' pro radiosensybilizujuchu diju preparata. Kljuchovi slova: shhury-samci, N-stearoi'letanolamin, ionizujuche vyprominjuvannja, stres, gematologichni pokaznyky, peryferychna krov.
