Melanoma in the Eyes of Mechanobiology

التفاصيل البيبلوغرافية
العنوان: Melanoma in the Eyes of Mechanobiology
المؤلفون: Brás, M. Manuela, Radmacher, Manfred, Sousa, Susana R., Granja, Pedro L.
المساهمون: Instituto de Investigação e Inovação em Saúde, Repositório Científico do Instituto Politécnico do Porto
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Frontiers in Cell and Developmental Biology
بيانات النشر: Frontiers Media, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Keratinocytes, Mechanobiology, Cell and Developmental Biology, MEchanobiology, Invasion, Metastization, Adhesion, Melanocytes, Cell Biology, Review, Melanoma, Migration, Developmental Biology
الوصف: Skin is the largest organ of the human body with several important functions that can be impaired by injury, genetic or chronic diseases. Among all skin diseases, melanoma is one of the most severe, which can lead to death, due to metastization. Mechanotransduction has a crucial role for motility, invasion, adhesion and metastization processes, since it deals with the response of cells to physical forces. Signaling pathways are important to understand how physical cues produced or mediated by the Extracellular Matrix (ECM), affect healthy and tumor cells. During these processes, several molecules in the nucleus and cytoplasm are activated. Melanocytes, keratinocytes, fibroblasts and the ECM, play a crucial role in melanoma formation. This manuscript will address the synergy among melanocytes, keratinocytes, fibroblasts cells and the ECM considering their mechanical contribution and relevance in this disease. Mechanical properties of melanoma cells can also be influenced by pigmentation, which can be associated with changes in stiffness. Mechanical changes can be related with the adhesion, migration, or invasiveness potential of melanoma cells promoting a high metastization capacity of this cancer. Mechanosensing, mechanotransduction, and mechanoresponse will be highlighted with respect to the motility, invasion, adhesion and metastization in melanoma cancer.
The authors acknowledge to Ana Silva (ana@anasilvaillustrations.com) for expert assistance with graphical design, and to Portuguese funds – FCT UID/BIM/04293/2019.
وصف الملف: application/pdf
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e1c295df1c328ecd935fdaf6a84fd53c
حقوق: OPEN
رقم الأكسشن: edsair.pmid.dedup....e1c295df1c328ecd935fdaf6a84fd53c
قاعدة البيانات: OpenAIRE