تقرير
Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy
| العنوان: | Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy |
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| المؤلفون: | Das, Chinmay, Sheik, Khizar H., Olmsted, Peter D., Connell, Simon D. |
| المصدر: | Phys. Rev. E 82, 041920 (2010) [6 pages] |
| سنة النشر: | 2010 |
| المجموعة: | Condensed Matter Physics (Other) |
| مصطلحات موضوعية: | Physics - Biological Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Condensed Matter - Soft Condensed Matter |
| الوصف: | We present theory and experiments for the force-distance curve $F(z_0)$ of an atomic force microscope (AFM) tip (radius $R$) indenting a supported fluid bilayer (thickness $2d$). For realistic conditions the force is dominated by the area compressibility modulus $\kappa_A$ of the bilayer, and, to an excellent approximation, given by $F= \pi \kappa_A R z_0^2/(2d-z_0)^2$. The experimental AFM force curves from coexisting liquid ordered and liquid disordered domains in 3-component lipid bilayers are well-described by our model, and provides $\kappa_A$ in agreement with literature values. The liquid ordered phase has a yield like response that we model by hydrogen bond breaking. Comment: 6 pages, 6 figures, accepted for publication in Physical Review E |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1103/PhysRevE.82.041920 |
| URL الوصول: | http://arxiv.org/abs/1006.3937 |
| رقم الأكسشن: | edsarx.1006.3937 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1103/PhysRevE.82.041920 |
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