تقرير
Quorum sensing contributes to activated B cell homeostasis and to prevent autoimmunity
| العنوان: | Quorum sensing contributes to activated B cell homeostasis and to prevent autoimmunity |
|---|---|
| المؤلفون: | Montaudouin, Caroline, Anson, Marie, Hao, Yi, Duncker, Susanne V., Fernandez, Tahia, Gaudin, Emmanuelle, Ehrenstein, Michael, Kerr, William G., Colle, Jean-Herve, Bruhns, Pierre, Daeron, Marc, Freitas, Antonio A. |
| سنة النشر: | 2012 |
| المجموعة: | Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Cell Behavior |
| الوصف: | Maintenance of plasma IgM levels is critical for immune system function and homeostasis in humans and mice. However, the mechanisms that control homeostasis of the activated IgM-secreting B cells are unknown. After adoptive transfer into immune-deficient hosts, B-lymphocytes expand poorly but fully reconstitute the pool of natural IgM-secreting cells and circulating IgM levels. By using sequential cell transfers and B cell populations from several mutant mice, we were able to identify novel mechanisms regulating the size of the IgM-secreting B cell pool. Contrary to previous mechanisms described regulating homeostasis, which involve competition for the same niche by cells having overlapping survival requirements, homeostasis of the innate IgM-secreting B cell pool is also achieved when B cells populations are able to monitor the number of activated B cells by detecting their secreted products. Notably, B cell populations are able to assess the density of activated B cells by sensing their secreted IgG. This process involves the Fc{\gamma}RIIB, a low-affinity IgG receptor that is expressed on B cells and acts as a negative regulator of B cell activation, and its intracellular effector the inositol phosphatase SHIP. As a result of the engagement of this inhibitory pathway the number of activated IgM-secreting B cells is kept under control. We hypothesize that malfunction of this quorum-sensing mechanism may lead to uncontrolled B cell activation and autoimmunity. Comment: 34 pages, 5 figures |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/1209.0337 |
| رقم الأكسشن: | edsarx.1209.0337 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |