تقرير
Efficient inference of protein structural ensembles
| العنوان: | Efficient inference of protein structural ensembles |
|---|---|
| المؤلفون: | Lane, Thomas J., Schwantes, Christian R., Beauchamp, Kyle A., Pande, Vijay S. |
| سنة النشر: | 2014 |
| المجموعة: | Physics (Other) Quantitative Biology |
| مصطلحات موضوعية: | Physics - Biological Physics, Quantitative Biology - Biomolecules |
| الوصف: | It is becoming clear that traditional, single-structure models of proteins are insufficient for understanding their biological function. Here, we outline one method for inferring, from experiments, not only the most common structure a protein adopts (native state), but the entire ensemble of conformations the system can adopt. Such ensemble mod- els are necessary to understand intrinsically disordered proteins, enzyme catalysis, and signaling. We suggest that the most difficult aspect of generating such a model will be finding a small set of configurations to accurately model structural heterogeneity and present one way to overcome this challenge. |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/1408.0255 |
| رقم الأكسشن: | edsarx.1408.0255 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |