تقرير
Effects of macromolecular crowding on the collapse of biopolymers
| العنوان: | Effects of macromolecular crowding on the collapse of biopolymers |
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| المؤلفون: | Kang, Hongsuk, Pincus, Philip A., Hyeon, Changbong, Thirumalai, D. |
| المصدر: | Phys. Rev. Lett. (2015) vol. 114, 068303 |
| سنة النشر: | 2014 |
| المجموعة: | Condensed Matter Physics (Other) Quantitative Biology |
| مصطلحات موضوعية: | Condensed Matter - Soft Condensed Matter, Physics - Biological Physics, Quantitative Biology - Biomolecules |
| الوصف: | Experiments show that macromolecular crowding modestly reduces the size of intrinsically disordered proteins (IDPs) even at volume fraction ($\phi$) similar to that in the cytosol whereas DNA undergoes a coil-to-globule transition at very small $\phi$. We show using a combination of scaling arguments and simulations that the polymer size $\overline{R}_g(\phi)$ depends on $x = \overline{R}_g(0)/D$ where $D$ is the $\phi$-dependent distance between the crowders. If $x\lesssim \mathcal{O}(1)$, there is only a small decrease in $\overline{R}_g(\phi)$ as $\phi$ increases. When $x\gg \mathcal{O}(1)$, a cooperative coil-to-globule transition is induced. Our theory quantitatively explains a number of experiments. Comment: 7 pages 5 figures, accepted in Phys. Rev. Lett |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1103/PhysRevLett.114.068303 |
| URL الوصول: | http://arxiv.org/abs/1409.5663 |
| رقم الأكسشن: | edsarx.1409.5663 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1103/PhysRevLett.114.068303 |
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