تقرير
Integral Control Feedback Circuit for the Reactivation of Malfunctioning p53 Pathway
| العنوان: | Integral Control Feedback Circuit for the Reactivation of Malfunctioning p53 Pathway |
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| المؤلفون: | Ooi, Hsu Kiang, Ma, Lan |
| سنة النشر: | 2015 |
| المجموعة: | Mathematics Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Molecular Networks, Mathematics - Dynamical Systems, Mathematics - Optimization and Control |
| الوصف: | We developed a strategy to control p53 levels when the p53 concentration falls below a desired threshold . Based on an established p53-MDM2 mathematical model that also incorporates microRNA regulators (p53-MDM2-miRNA), we applied a control action in closed-loop with respect to this model. In particular, we employ various architectures of synthetic circuit with integral feedback control, illustrating varying degree in adaptive response to step-wise perturbation of p53. Comment: 23 pages. 8 figures. Theoretical model of synthetic circuit that implements integral control feedback |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/1510.04136 |
| رقم الأكسشن: | edsarx.1510.04136 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |