تقرير
Protein Lipograms
| العنوان: | Protein Lipograms |
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| المؤلفون: | Laurie, Jason, Chattopadhyay, Amit K, Flower, Darren R |
| المصدر: | Journal of Theoretical Biology, vol 430, pg 109, 2017 |
| سنة النشر: | 2017 |
| المجموعة: | Physics (Other) Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Quantitative Methods, Physics - Biological Physics |
| الوصف: | Linguistic analysis of protein sequences is an underexploited technique. Here, we capitalize on the concept of the lipogram to characterize sequences at the proteome levels. A lipogram is a literary composition which omits one or more letters. A protein lipogram likewise omits one or more types of amino acid. In this article, we establish a usable terminology for the decomposition of a sequence collection in terms of the lipogram. Next, we characterize Uniref50 using a lipogram decomposition. At the global level, protein lipograms exhibit power-law properties. A clear correlation with metabolic cost is seen. Finally, we use the lipogram construction to differentiate proteomes between the four branches of the tree-of-life: archaea, bacteria, eukaryotes and viruses. We conclude from this pilot study that the lipogram demonstrates considerable potential as an additional tool for sequence analysis and proteome classification. Comment: 8 pages, 2 columns, 5 figures |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1016/j.jtbi.2017.07.009 |
| URL الوصول: | http://arxiv.org/abs/1707.08984 |
| رقم الأكسشن: | edsarx.1707.08984 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1016/j.jtbi.2017.07.009 |
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