تقرير
An axon initial segment is required for temporal precision in action potential encoding by neuronal populations
العنوان: | An axon initial segment is required for temporal precision in action potential encoding by neuronal populations |
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المؤلفون: | Lazarov, Elinor, Dannemeyer, Melanie, Feulner, Barbara, Enderlein, Jörg, Gutnick, Michael J., Wolf, Fred, Neef, Andreas |
المصدر: | Science Advances Vol. 4, no. 11, eaau8621; 28 Nov 2018 |
سنة النشر: | 2017 |
المجموعة: | Quantitative Biology |
مصطلحات موضوعية: | Quantitative Biology - Neurons and Cognition |
الوصف: | Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular nanoscale pattern. Although the AIS was a key evolutionary innovation in neurons, the functional benefits it confers are not clear. Using a mutation of the AIS cytoskeletal protein \beta IV-spectrin, we here establish an in vitro model of neurons with a perturbed AIS architecture that retains nanoscale order but loses the ability to maintain a high NaV density. Combining experiments and simulations we show that a high NaV density in the AIS is not required for axonal AP initiation; it is however crucial for a high bandwidth of information encoding and AP timing precision. Our results provide the first experimental demonstration of axonal AP initiation without high axonal channel density and suggest that increasing the bandwidth of the neuronal code and hence the computational efficiency of network function was a major benefit of the evolution of the AIS. Comment: Title adjusted, no other changes |
نوع الوثيقة: | Working Paper |
DOI: | 10.1126/sciadv.aau8621 |
URL الوصول: | http://arxiv.org/abs/1711.03383 |
رقم الأكسشن: | edsarx.1711.03383 |
قاعدة البيانات: | arXiv |
DOI: | 10.1126/sciadv.aau8621 |
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