تقرير
Quantifying Genetic Innovation: Mathematical Foundations for the Topological Study of Reticulate Evolution
| العنوان: | Quantifying Genetic Innovation: Mathematical Foundations for the Topological Study of Reticulate Evolution |
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| المؤلفون: | Lesnick, Michael, Rabadán, Raúl, Rosenbloom, Daniel I. S. |
| سنة النشر: | 2018 |
| المجموعة: | Computer Science Mathematics Quantitative Biology |
| مصطلحات موضوعية: | Mathematics - Algebraic Topology, Computer Science - Computational Geometry, Quantitative Biology - Populations and Evolution, Quantitative Biology - Quantitative Methods |
| الوصف: | A topological approach to the study of genetic recombination, based on persistent homology, was introduced by Chan, Carlsson, and Rabad\'an in 2013. This associates a sequence of signatures called barcodes to genomic data sampled from an evolutionary history. In this paper, we develop theoretical foundations for this approach. First, we present a novel formulation of the underlying inference problem. Specifically, we introduce and study the novelty profile, a simple, stable statistic of an evolutionary history which not only counts recombination events but also quantifies how recombination creates genetic diversity. We propose that the (hitherto implicit) goal of the topological approach to recombination is the estimation of novelty profiles. We then study the problem of obtaining a lower bound on the novelty profile using barcodes. We focus on a low-recombination regime, where the evolutionary history can be described by a directed acyclic graph called a galled tree, which differs from a tree only by isolated topological defects. We show that in this regime, under a complete sampling assumption, the $1^\mathrm{st}$ barcode yields a lower bound on the novelty profile, and hence on the number of recombination events. For $i>1$, the $i^{\mathrm{th}}$ barcode is empty. In addition, we use a stability principle to strengthen these results to ones which hold for any subsample of an arbitrary evolutionary history. To establish these results, we describe the topology of the Vietoris--Rips filtrations arising from evolutionary histories indexed by galled trees. As a step towards a probabilistic theory, we also show that for a random history indexed by a fixed galled tree and satisfying biologically reasonable conditions, the intervals of the $1^{\mathrm{st}}$ barcode are independent random variables. Using simulations, we explore the sensitivity of these intervals to recombination. Comment: Expository improvements and minor corrections. To appear in the SIAM Journal on Applied Algebra and Geometry. 47 pages |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/1804.01398 |
| رقم الأكسشن: | edsarx.1804.01398 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |