A multidisciplinary approach is presented to analyse the precipitation process in a model Al-Cu alloy. Although this topic has been extensively studied in the past, most of the investigations are focussed either on transmission electron microscopy or on thermal analysis of the processes. The information obtained from these techniques cannot, however, provide a coherent picture of all the complex transformations that take place during decomposition of supersaturated solid solution. Thermal analysis, high resolution dilatometry, (high resolution) transmission electron microscopy and density functional calculations are combined to study precipitation kinetics, interfacial energies, and the effect of second phase precipitates on the mechanical strength of the alloy. Data on both the coherent and semi-coherent orientations of the {\theta}"/Al interface are reported for the first time. The combination of the different characterization and modelling techniques provides a detailed picture of the precipitation phenomena that take place during aging and of the different contributions to the strength of the alloy. This strategy can be used to analyse and design more complex alloys.
