تقرير
Horseshoe-based Bayesian nonparametric estimation of effective population size trajectories
| العنوان: | Horseshoe-based Bayesian nonparametric estimation of effective population size trajectories |
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| المؤلفون: | Faulkner, James R., Magee, Andrew F., Shapiro, Beth, Minin, Vladimir N. |
| سنة النشر: | 2018 |
| المجموعة: | Quantitative Biology Statistics |
| مصطلحات موضوعية: | Statistics - Methodology, Quantitative Biology - Populations and Evolution |
| الوصف: | Phylodynamics is an area of population genetics that uses genetic sequence data to estimate past population dynamics. Modern state-of-the-art Bayesian nonparametric methods for recovering population size trajectories of unknown form use either change-point models or Gaussian process priors. Change-point models suffer from computational issues when the number of change-points is unknown and needs to be estimated. Gaussian process-based methods lack local adaptivity and cannot accurately recover trajectories that exhibit features such as abrupt changes in trend or varying levels of smoothness. We propose a novel, locally-adaptive approach to Bayesian nonparametric phylodynamic inference that has the flexibility to accommodate a large class of functional behaviors. Local adaptivity results from modeling the log-transformed effective population size a priori as a horseshoe Markov random field, a recently proposed statistical model that blends together the best properties of the change-point and Gaussian process modeling paradigms. We use simulated data to assess model performance, and find that our proposed method results in reduced bias and increased precision when compared to contemporary methods. We also use our models to reconstruct past changes in genetic diversity of human hepatitis C virus in Egypt and to estimate population size changes of ancient and modern steppe bison. These analyses show that our new method captures features of the population size trajectories that were missed by the state-of-the-art methods. Comment: 36 pages, including supplementary information |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1111/biom.13276 |
| URL الوصول: | http://arxiv.org/abs/1808.04401 |
| رقم الأكسشن: | edsarx.1808.04401 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1111/biom.13276 |
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