We prove a double commutant theorem for separable subalgebras of a wide class of corona C*-algebras, largely resolving a problem posed by Pedersen. Double commutant theorems originated with von Neumann, whose seminal result evolved into an entire field now called von Neumann algebra theory. Voiculescu later proved a C*-algebraic double commutant theorem for subalgebras of the Calkin algebra. We prove a similar result for subalgebras of a much more general class of so-called corona C*-algebras.