تقرير
A Data-Validated Host-Parasite Model for Infectious Disease Outbreaks
| العنوان: | A Data-Validated Host-Parasite Model for Infectious Disease Outbreaks |
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| المؤلفون: | Tadiri, Christina P., Kong, Jude D., Fussmann, Gregor F., Scott, Marilyn E., Wang, Hao |
| سنة النشر: | 2019 |
| المجموعة: | Mathematics Quantitative Biology Statistics |
| مصطلحات موضوعية: | Quantitative Biology - Populations and Evolution, Mathematics - Dynamical Systems, Statistics - Computation |
| الوصف: | The use of model experimental systems and mathematical models is important to further understanding of infectious disease dynamics and strategize disease mitigation. Gyrodactylids are helminth ectoparasites of teleost fish which have many dynamical characteristics of microparasites but offer the advantage that they can be quantified and tracked over time, allowing further insight into within-host and epidemic dynamics. In this paper, we design a model to describe host-parasite dynamics of the well-studied guppy-Gyrodactylus turnbulli system, using experimental data to estimate parameters and validate it. We estimate the basic reproduction number (R_0), for this system. Sensitivity analysis reveals that parasite growth rate, and the rate at which the guppy mounts an immune response have the greatest impact on outbreak peak and timing both for initial outbreaks and on longer time scales. These findings highlight guppy population resistance and parasite virulence as key factors in disease control, and future work should focus on incorporating heterogeneity in host resistance into disease models and extrapolating to other host-parasite systems. Comment: * Equally contributing first authors |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.3389/fevo.2019.00307 |
| URL الوصول: | http://arxiv.org/abs/1907.00249 |
| رقم الأكسشن: | edsarx.1907.00249 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.3389/fevo.2019.00307 |
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