تقرير
Jamming and force distribution in growing epithelial tissue
| العنوان: | Jamming and force distribution in growing epithelial tissue |
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| المؤلفون: | Madhikar, Pranav, Åström, Jan, Baumeier, Björn, Karttunen, Mikko |
| المصدر: | Phys. Rev. Research 3, 023129 (2021) |
| سنة النشر: | 2020 |
| المجموعة: | Condensed Matter Physics (Other) Quantitative Biology |
| مصطلحات موضوعية: | Condensed Matter - Soft Condensed Matter, Physics - Biological Physics, Quantitative Biology - Cell Behavior |
| الوصف: | We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The model is applied to a bimodal mixture consisting of stiff cells with a low growth potential and soft cells with a high growth potential; cancer cells are typically considered to be softer than healthy cells. In an even mixture, the soft cells develop into a tissue matrix and the stiff cells into a dendrite-like network structure. When soft cells are placed inside a tissue consisting of stiff cells (to model cancer growth), the soft cells develop to a fast growing tumor-like structure that gradually evacuates the stiff cell matrix. The model also demonstrates 1) how soft cells orient themselves in the direction of the largest effective stiffness as predicted by the theory of Bischofs and Schwarz (Proc. Natl. Acad. Sci U.S.A., 100, 9274--9279 (2003) and 2) that the orientation and force generation continue a few cell rows behind the soft-stiff interface. With increasing inter-cell friction, tumor growth slows down and cell death occurs. The contact force distribution between cells is demonstrated to be highly sensitive to cell type mixtures and cell-cell interactions, which indicates that local mechanical forces can be useful as a regulator of tissue formation. The results shed new light on established experimental data. Comment: arXiv admin note: text overlap with arXiv:1811.07573 |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1103/PhysRevResearch.3.023129 |
| URL الوصول: | http://arxiv.org/abs/2005.02375 |
| رقم الأكسشن: | edsarx.2005.02375 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1103/PhysRevResearch.3.023129 |
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