تقرير
Improve it or lose it: evolvability costs of competition for expression
| العنوان: | Improve it or lose it: evolvability costs of competition for expression |
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| المؤلفون: | Moran, Jacob, Finlay, Devon, Tikhonov, Mikhail |
| المصدر: | Phys. Rev. E 103, 062402 (2021) |
| سنة النشر: | 2020 |
| المجموعة: | Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Populations and Evolution |
| الوصف: | Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of proteins. Having implications in both directions fosters the possibility of a feedback loop, where higher expressed systems are more likely to improve and be expressed even higher, while those that are expressed less are eventually lost to drift. Using a minimal model to study this in the context of a changing environment, we demonstrate that one unexpected consequence of such a feedback loop is that a slow switch to a new environment can allow genotypes to reach higher fitness sooner than a direct exposure to it. Comment: 6 pages, 4 figures + Supplementary Material |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1103/PhysRevE.103.062402 |
| URL الوصول: | http://arxiv.org/abs/2012.09325 |
| رقم الأكسشن: | edsarx.2012.09325 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1103/PhysRevE.103.062402 |
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