In this article we study a theory of support varieties over a skew complete intersection $R$, i.e. a skew polynomial ring modulo an ideal generated by a sequence of regular normal elements. We compute the derived braided Hochschild cohomology of $R$ relative to the skew polynomial ring and show its action on $\mathrm{Ext}_R(M,N)$ is noetherian for finitely generated $R$-modules $M$ and $N$ respecting the braiding of $R$. When the parameters defining the skew polynomial ring are roots of unity we use this action to define a support theory. In this setting applications include a proof of the Generalized Auslander-Reiten Conjecture and that $R$ possesses symmetric complexity.
