تقرير
Forecasting Avalanches in Branched Actomyosin Networks with Network Science and Machine Learning
| العنوان: | Forecasting Avalanches in Branched Actomyosin Networks with Network Science and Machine Learning |
|---|---|
| المؤلفون: | Li, Chengxuan, Liman, James, Eliaz, Yossi, Cheung, Margaret S |
| سنة النشر: | 2021 |
| المجموعة: | Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Molecular Networks |
| الوصف: | We explored the dynamical and structural effects of actin-related proteins 2/3 (Arp2/3) on actomyosin networks using mechanochemical simulations of active matter networks. At a nanoscale, the Arp2/3 complex alters the topology of actomyosin by nucleating a daughter filament at an angle to a mother filament. At a subcellular scale, they orchestrate the formation of branched actomyosin network. Using a coarse-grained approach, we sought to understand how an actomyosin network temporally and spatially reorganizes itself by varying the concentration of the Arp2/3 complexes. Driven by the motor dynamics, the network stalls at a high concentration of Arp2/3 and contracts at a low Arp2/3 concentration. At an intermediate Arp2/3 concentration, however, the actomyosin network is formed by loosely connected clusters that may collapse suddenly when driven by motors. This physical phenomenon is called an "avalanche" largely due to the marginal instability inherent from the morphology of a branched actomyosin network when the Arp2/3 complex is present. While embracing the data science approaches, we unveiled the higher-order patterns in the branched actomyosin networks and discovered a sudden change in the "social" network topology of the actomyosin. This is a new type of avalanches in addition to the two types of avalanches associated with a sudden change in the size or the shape of the whole actomyosin network as shown in the previous investigation. Our new finding promotes the importance of using network theory and machine learning models to forecast avalanches in actomyosin networks. The mechanisms of the Arp2/3 complexes in shaping the architecture of branched actomyosin networks obtained in this paper will help us better understand the emergent reorganization of the topology in dense actomyosin networks that are difficult to detect in experiments. Comment: Submitted |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2106.04005 |
| رقم الأكسشن: | edsarx.2106.04005 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |