تقرير
Thermodynamic bounds on ultrasensitivity in covalent switching
| العنوان: | Thermodynamic bounds on ultrasensitivity in covalent switching |
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| المؤلفون: | Owen, Jeremy A., Talla, Pranay, Biddle, John W., Gunawardena, Jeremy |
| سنة النشر: | 2022 |
| المجموعة: | Condensed Matter Physics (Other) Quantitative Biology |
| مصطلحات موضوعية: | Quantitative Biology - Molecular Networks, Condensed Matter - Statistical Mechanics, Physics - Biological Physics |
| الوصف: | Switch-like motifs are among the basic building blocks of biochemical networks. A common motif that can serve as an ultrasensitive switch consists of two enzymes acting antagonistically on a substrate, one making and the other removing a covalent modification. To work as a switch, such covalent modification cycles must be held out of thermodynamic equilibrium by continuous expenditure of energy. Here, we exploit the linear framework for timescale separation to establish tight bounds on the performance of any covalent-modification switch, in terms of the chemical potential difference driving the cycle. The bounds apply to arbitrary enzyme mechanisms, not just Michaelis-Menten, with arbitrary rate constants, and thereby reflect fundamental physical constraints on covalent switching. Comment: 29 pages, 6 figures |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1016/j.bpj.2023.04.015 |
| URL الوصول: | http://arxiv.org/abs/2211.10472 |
| رقم الأكسشن: | edsarx.2211.10472 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1016/j.bpj.2023.04.015 |
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