تقرير
Controlling topological defects and contractile flow in confined nematic cell population
| العنوان: | Controlling topological defects and contractile flow in confined nematic cell population |
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| المؤلفون: | Ienaga, Ryo, Beppu, Kazusa, Maeda, Yusuke T. |
| المصدر: | Soft Matter 19, 5016-5028 (2023) |
| سنة النشر: | 2022 |
| المجموعة: | Condensed Matter Physics (Other) |
| مصطلحات موضوعية: | Condensed Matter - Soft Condensed Matter, Physics - Biological Physics |
| الوصف: | Topological defects in nematically aligned cell populations play a critical role in modulating collective motion, from microbial colonies to epithelial tissues. Despite the potential of manipulating such topological defects to control diverse self-organized structures and collective dynamics, defect manipulation in active matter remains an challenging area of research. In this study, we investigated the geometric control of defect positioning and alignment in a nematic cell population by imposing spatial constraints consisting of two or three overlapping circular boundaries. The confined cell population exhibited an ordered pairing of half-integer topological defects that remained stable even when the size of the spatial constraint was altered using geometric parameters. These defects also elicited robust contractile flow that induced a negative divergence in the velocity field of collective motion. Such net contractile flow can contribute to mechanical stimulation on confined cells, as evidenced by the stretched cell nucleus. Our geometry-based approach paves the way for controlling defect pairing, providing a deeper understanding of the interplay among geometry, topology, and collective dynamics. Comment: 9 pages, 5 figures |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1039/D3SM00071K |
| URL الوصول: | http://arxiv.org/abs/2212.13756 |
| رقم الأكسشن: | edsarx.2212.13756 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1039/D3SM00071K |
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